Treatment with G150, a specific cGAS inhibitor, significantly decreased both 2′3′cGAMP activity and IFN-β synthesis in SSc fibroblasts (Paul et al., 2022), confirming the role of micronuclei in activating cGAS-STING signaling and subsequent IFN-β production (Paul et al., 2022). Here, CGAS is linked to systemic sclerosis.