The overactivation of NF-κB caused by the blockage of SIRT1 promotes the generation of ROS, forming an oxidative stress-inflammation positive feedback loop, exacerbating renal damage, testicular spermatogenesis disorders, and sperm DNA damage (Suleiman et al., 2020; Yuan et al., 2022).Previous research has shown that treatment with the SIRT1 agonist BF175 in CKD mice significantly attenuates NF-κB activation and the expression of senescence and inflammatory markers, thereby reducing albuminuria and the progression of CKD (Feng et al., 2021). Here, SIRT1 is linked to chronic kidney disease.