Instead, CBX7 inhibition of AML cells induced differentiation, as shown by increased expression of the differentiation markers CD11b (Figure 4E,G; supplemental Figure 5A-B) and CD14 (Figure 4F,H), of which CD11b is not expressed and CD14 is moderately expressed by undifferentiated OCI-AML3 cells. Here, RUNX2 is linked to acute myeloid leukemia.