CBX7 and acute myeloid leukemia: Furthermore, we observed that the majority of AML cells undergo apoptosis after treatment with CBX7 inhibitors, as shown by an excess of annexin-V–positive, 7-aminoactinomycin D–positive cells, instead of nonapoptotic cell death shown by a small number of annexin-V–positive, 7-aminoactinomycin D–positive cells after CBX7 inhibitor treatment (Figure 4J-K; supplemental Figure 5I-J).