PTPN6 and acute lymphoblastic leukemia: We were unable to identify obvious DNA methylation alterations that could explain this (Figure 1E) and although expression of upstream regulators was increased in murine Dnmt3aKO T-ALL cells (supplemental Figure 4B), levels of the core components was largely similar to control T-All cells, with the exception of Ptpn6 (supplemental Figure 4C).