We repeated the drug treatment experiments in the presence of RUX, which resensitized cells from patients with DNMT3A-mutant T-ALL to apoptosis (Figure 5D), confirming JAK/STAT signaling potentiates the chemotherapy resistance phenotype of DNMT3A-mutant T-ALL (Figure 5E). The gene discussed is DNMT3A; the disease is acute lymphoblastic leukemia.