It controls the trafficking and recycling of receptor tyrosine kinases (RTKs) like EGFR and HER2, impacting cell proliferation, survival, and migration.43,44 Its activity also influences mTOR signaling by modulating amino acid sensing and lysosomal functions, crucial for cell growth and metabolism.45 Additionally, V-ATPase regulates the acidification of endosomes, necessary for activating the Wnt signaling pathway, often dysregulated in cancer. The gene discussed is EGFR; the disease is cancer.