A low dose ACTH test was performed (1 mcg Synachten), showing an inadequate secretion of cortisol poststimulus (cortisol peak at 40 min: 1.8 μg/dL; normal range 6.7–22.6 μg/dL), confirming secondary adrenal insufficiency. The gene discussed is POMC; the disease is Adrenal insufficiency.