ISGs, such as IFIT and IFITM, ISG15, IFIH1, MX1, IRF7, OAS 1-3, and STAT1 are recognized for enhancing IFN signaling, thereby contributing to antiviral activity, emerge as potential candidates for drug targets in COVID-19 treatment (Prasad et al., 2020). Here, ISG15 is linked to COVID-19.