ZBTB16, Also known as myeloid leukemia zinc finger protein (PLZF), it was first discovered in 1993 in the study of acute myeloid leukemia, and as a transcription inhibitory factor, it may affect the tumor immune microenvironment by regulating the NF - κ B pathway (Liu D. et al., 2024). Here, ZBTB16 is linked to acute myeloid leukemia.