However, while rs2234693, rs9340799 and rs8179176 in ESR1 gene and rs4986938 in ESR2 gene were significantly associated with PCOS in Pakistani women (22), no significant associations between the variants of ESR1 rs2234693, ESR1 rs9340799 were observed in a Caucasian population (23). Here, ESR2 is linked to polycystic ovary syndrome.