A genetic study used Sanger sequencing to search for six known SNPs in LHCGR (rs2293275), FSHR (rs6166), ESR1 (rs2234693), GnRHR (rs104893836), miR-126 (rs4636297), and miR-499 (rs3746444) among 8 familial PCOS cases and 3 sporadic patients. The gene discussed is GNRHR; the disease is polycystic ovary syndrome.