Polymorphisms in LEPR may lead to altered structure and function of the leptin receptor, impairing the leptin-associated signaling pathway, which, in turn, could inhibit the beneficial effects of leptin and contribute to insulin resistance and T2DM [18]. However, it is important to note that leptin levels were not measured in this study, which may limit the ability to directly correlate these genetic variants with the functional effects of leptin in this population. The gene discussed is LEP; the disease is Insulin resistance.