GPER1 and Cognitive impairment: The phytoestrogen Secoisolariciresinol diglucoside (SDG) promotes the production of the gut microbial metabolites END and ENL, inhibits cerebral Aβ deposition, activates GPER to enhance the CREB/BDNF signaling pathway and suppresses the neuroinflammatory response to ameliorate cognitive deficits (107).