17β-estradiol can be activated by PI3K/AKT signaling mediated by ERβ and GPR30 to alleviate postmenopausal dyslipidemia (91), and also upregulates the ERα/SIRT1/PGC-1α signaling pathway, protecting mitochondrial function and preventing lipoatrophy (92). This evidence concerns the gene ESR2 and metabolic syndrome.