ESR1 and Cognitive impairment: Other studies found that E2 levels and the expression of ERα, ERβ and GPER in OVX mice were significantly reduced, and there was a significant correlation with dyslipidemia and cognitive impairment, E2 supplementation or lipid lowering is an effective method to ameliorate postmenopausal hyperlipidemia induced hippocampal damage and cognitive impairment by upregulating ERs (36).