Other studies found that E2 levels and the expression of ERα, ERβ and GPER in OVX mice were significantly reduced, and there was a significant correlation with dyslipidemia and cognitive impairment, E2 supplementation or lipid lowering is an effective method to ameliorate postmenopausal hyperlipidemia induced hippocampal damage and cognitive impairment by upregulating ERs (36). Here, GPER1 is linked to metabolic syndrome.