brain-derived neurotrophic factor (BDNF) is a neurotrophic factor that is essential for maintaining brain function, there is a strong association between reduced levels of BDNF and the development of depression, and estrogen regulates BDNF expression, which promotes neurogenesis, synaptic plasticity, and neuronal survival and contributes to emotion improvement (49). The gene discussed is BDNF; the disease is depressive symptom measurement.