SFN alleviated depression-like behaviors by reducing TNF-α levels, microglial activation, and inflammation. It also enhanced neuroprotection and plasticity (276–278)SFN alleviated the ASD symptoms in mice and humans, evidenced by the improved verbal and non-verbal communication score, possibly due to the activation of Nrf2 (282, 283). The gene discussed is TNF; the disease is major depressive disorder.