Plasma procalcitonin (PCT) levels are indicative of inflammation, with adipose tissue acting as an endocrine organ that produces calcitonin mRNA. In vitro studies show that adipocytes release procalcitonin in response to activated macrophages. A positive correlation exists between BMI z‐score and procalcitonin levels, establishing a direct relationship between increased adipose tissue volume and heightened production of inflammatory mediators in obesity‐induced inflammation. This evidence concerns the gene CALCA and Obesity.