Plasma procalcitonin (PCT) levels are indicative of inflammation, with adipose tissue acting as an endocrine organ that produces calcitonin mRNA. In vitro studies show that adipocytes release procalcitonin in response to activated macrophages. A positive correlation exists between BMI z‐score and procalcitonin levels, establishing a direct relationship between increased adipose tissue volume and heightened production of inflammatory mediators in obesity‐induced inflammation. The gene discussed is CALCA; the disease is obesity due to melanocortin 4 receptor deficiency.