GPT and obesity due to melanocortin 4 receptor deficiency: In children and adolescents with obesity, miR‐222, miR‐142‐3, miR‐140‐5p, and miR‐143 are upregulated, affecting hepatic function and cholesterol synthesis. Elevated miR‐122 levels are linked to liver steatosis, NAFLD progression, and increased ALT, AST, GGT, triglycerides, and reduced HDL cholesterol.