GPNMB and cancer: Consequently, we identified five cancer stem cell-based interactions with macrophages, CD8+ cytotoxic T cells, natural killer cells, and plasma cells and matched 33 ligand-receptor marker genes, includingANPEP,BAAT,CD14,CD163,CD24,CD33,CD40,CD63,CD68,CD69,CD81,CD86,CD9,CSF1R,CXCL10,CXCL2,CXCL9,FCGR1A,FCGR2A,FCGR2B,FCGR3A,GPC3,GPNMB,IL7R,ITGAM,ITGAX,KLRB1,LAMP2,LGALS3,PECAM1,TLR2,TNFSF10, andTREM1 (Figure 3B).