CD274 and neoplasm: The molecular intervention obstructs programmed cell death protein 1 (PD‐1)/programmed death‐ligand 1 (PD‐L1) axis‐mediated coinhibitory signaling that normally maintains immunological tolerance, consequently reversing T cell exhaustion phenotypes and augmenting lymphocyte‐mediated tumoricidal activity within the tumor microenvironment (Figure 1A).