Serum biomarkers such as alpha‐fetoprotein (AFP), vitamin K deficiency‐II‐induced proteins, and AFP‐L3, AFP, des‐gamma‐carboxy prothrombin (DCP), and Des‐γ‐carboxyprothrombinogen (GALAD) scores have now been recommended for monitoring HCC [33, 34]. This evidence concerns the gene ACE and hepatocellular carcinoma.