Because both increase and decrease of SYT13 protein level affected the extracellular vesicle release in vitro, we investigated the changes in SYT13 in the synaptosome fraction of the human brains [DLB n = 5 and control n = 4; MSA n = 3 and control n = 3] (Fig. 8a–e, g–k). The gene discussed is SYT13; the disease is multiple system atrophy.