Next, to gain insight into the mechanisms by which NEC-driving factors increase CRBN expression, we analyzed publicly available ChIP-seq data for key NEC-driving transcription factors, primarily generated in relevant cell lines (Neuroblastoma, SCLC, and NEPC—all classified as small cell neuroendocrine cancers) (Supplementary Figure S9A). The gene discussed is CRBN; the disease is neuroendocrine carcinoma.