GSPT1 and hematopoietic and lymphoid cell neoplasm: These results align with prior studies demonstrating the strong anti-leukemic activity of GSPT1 MGDs [17, 18, 27, 28] and suggest shared transcriptomic features between NECs and hematological cancers, providing a strong rationale for exploring GSPT1 MGDs in these malignancies (Fig. 8).