Western blotting revealed greater LDH-A and PDK-1 expression in 4T1 tumors than in 67NR tumors (p < 0.05 and p < 0.0001, respectively, Fig. 5A, B), suggesting that aggressive and metastatic breast tumors may depend on glycolysis to sustain tumor progression. The gene discussed is LDHA; the disease is breast neoplasm.