We found that ICTs (CD24 on IgD+ CD38br and CD3 on CD28+ CD4+) influence asthma through two pathways, mediated by PMs (S‐methylcysteine sulfoxide levels and 1‐myristoyl‐2‐arachidonoyl‐GPC [14:0/20:4] levels). This evidence concerns the gene CD28 and asthma.