Although previous work has suggested a correlation between loss of the timer pathway and WIP1 mutation in aneuploid p53 wild-type tumour cell lines (Meitinger et al, 2024), these cells often have high continued levels of either replication stress or DNA damage (Chunduri and Storchova, 2019; Zhu et al, 2018). The gene discussed is PPM1D; the disease is neoplasm.