However, scrib mutant clones are actively eliminated through tumor-suppressive cell competition and exhibit reduced size compared to the wild-type (WT) clones (Fig. 1A,B) (Chen et al, 2012; Katsukawa et al, 2018; Ohsawa et al, 2011; Yamamoto et al, 2017). The gene discussed is SCRIB; the disease is neoplasm.