SCRIB and neoplasm: More importantly, under tumor-induced pathological conditions, fat body-specific inhibition of the JAK-STAT signaling suppresses QykiACT/scrib−/−-induced upregulation of Hippo target genes (Fig. EV7U), while the knockdown of sd specifically in the fat bodies inhibits QykiACT/scrib−/−-induced tumor progression and Spz5 induction in the fat body (Figs. 6O–R and EV7V).