In line with the potential tumor-promoting role of the Spz5-Toll-6 axis, we found that knockdown of spz5 in adipose tissue using the Cg-Gal4 (labels both adipose tissue and hemocytes) or the adipose tissue-specific promoter r4-Gal4 significantly inhibited the overgrowth and VNC invasion of QykiACT/scrib−/− tumors (Figs. 1M–O and EV1D–F). The gene discussed is CTSG; the disease is neoplasm.