SOAT1 and neoplasm: Notably, genetic inhibition of JAK-STAT pathway specifically in the fat bodies, by expressing domeDN, or by knockdown of hop (JAK) or Stat92E (STAT), not only significantly suppressed the overgrowth and invasion of QykiACT/scrib−/− tumors (Figs. 6I,J and EV7L) but also impeded tumor-induced upregulation of Spz5 in these tissues (Figs. 6I,K and EV7M).