To further investigate whether activation of the Hh pathway is essential for the progression of QMARCM-induced QykiACT/scrib−/− tumors, we blocked Hh activation by co-depleting ci and smo or by expressing ptc. This intervention resulted in a notable suppression of tumor overgrowth and VNC invasion (Figs. 3G,H and EV3P). The gene discussed is SMO; the disease is neoplasm.