SMO and neoplasm: Furthermore, overexpression of AP-2α effectively rescued the Toll-6 activation-induced membrane accumulation of Smo (Fig. 4E,F), hindered the upregulation of Ci (Fig. 4G), and importantly, inhibited tumor overgrowth and VNC invasion caused by ykiS168A/Toll-6ACT (Figs. 4H and EV5D,E).