CD274 and neoplasm: Our study uncovers a novel interorgan communication axis between adipose tissue and tumors in Drosophila. In mammals, adipokines and the tumor microenvironment can similarly form a bidirectional positive feedback network through metabolic reprogramming (e.g., FFA exchange), inflammatory signaling (e.g., TNF-α/NF-κB pathways), or immune checkpoint regulation (e.g., PD-L1, CCL2) (Mukherjee et al, 2023; Mukherjee et al, 2022; Song et al, 2024; Wu et al, 2023; Wu et al, 2021).