PLOD1 and polycystic ovary syndrome: The rat model of PCOS induced by 5–6 weeks of treatment with dehydroepiandrosterone (DHEA) mimics several characteristics of human PCOS, such as hyperandrogenism, acyclicity, abnormal ovarian follicle maturation, and anovulation [15] Serum levels of androgens, estrogens, and luteinizing hormone (LH) have been demonstrated to increase in this animal model [16, 17].