Patients with F4 liver fibrosis tended to be older with a mean age of 46.5 ± 6.96 years, with significantly higher values of BMI, bilirubin, AST, ALT, INR, FIB-4, and APRI scores (p < 0.001), while total protein, albumin, Hb, platelets and APP values were significantly lower (p < 0.001) (Tables 2a and 2b; Fig. 2). This evidence concerns the gene APP and Hepatic fibrosis.