CD226 and systemic sclerosis: Several GWAS have reported associations between the nonsynonymous rs763361 polymorphism in CD226 and SLE,[33–36] rheumatoid arthritis,[36,38–40] and systemic sclerosis.[43,44] In addition, some studies on immune cells, including our group, have suggested the involvement of CD226 in autoimmune diseases.[28,31,37,41,45] Regarding the association between CD226 and LVV, there are few GWAS and no immunological studies; only one Spanish study showed that CD226 gene variants are not involved in GCA,[46] and the association between CD226 gene variants and TAK is not revealed.