ACE and Peripheral edema: Angiotensin-converting enzyme inhibitor (ACEI) appear to be more effective than Ang II receptor blocker (ARB) in reducing CCBs-related peripheral edema, though further comparative studies are required to substantiate this.[50] However, attention should be given to the issue of “prescription cascade,” which refers to the phenomenon where an adverse reaction to 1 drug leads to the prescription of another drug to address those side effects, which in turn may cause new adverse effects, triggering a cycle of prescriptions.