It is mainly produced by activated macrophages, dendritic cells and other immune cells, and plays an important role in inflammation and immune response.MIP-1β participates in the regulation of inflammation and immune response by directing various types of immune cells to the site of inflammation through binding to its receptor CCR5.[29] Compared with normal controls, CCL4 is specifically upregulated in ischemic cardiomyopathy.[30] These are consistent with the results of the study. Here, CCR5 is linked to ischemic cardiomyopathy.