TNF and rheumatoid arthritis: These cytokines may serve as biomarkers for auxiliary diagnosis, disease progression assessment, and targeted therapy guidance, thereby improving patient outcomes.[28] Our results showed significant increases in IFN-α, IFN-γ, IL-10, IL-12P70, IL-2, IL-4, IL-5, IL-6, IL-8, TNF-α, and IL-1β levels in patients with RA.