RP is a rare immunologically related disease, with an annual incidence rate of approximately 0.7 to 9.0 cases per million people.[3] The pathogenesis of RP remains unclear, and antibodies specific to cartilage proteins, such as antitype II collagen and anti-matrilin-1, lack sensitivity and specificity. The gene discussed is MATN1; the disease is retinitis pigmentosa 1.