Using the XGBoost‐based model, key biomarkers including F11, ITIH4, SERPINA3, APMAP, ORM1, LRG1, ITIH3, FN1, FGL1, FCN3, C1QA, C5, PLTP, TPM3, and IGKV3‐64D were identified as critical variables for BD diagnosis (Figure 2C,D). This evidence concerns the gene LRG1 and Behcet disease.