The investigation further elucidated a potential mechanism by which LRG1 exacerbated cerebral ischemia‐reperfusion injury through upregulation of ALK1 expression, thereby activating the TGFβ‐Smad1/5 signaling pathway to mediate apoptotic cell death and autophagic processes.[21] Subsequently, Feng et al. This evidence concerns the gene SMAD1 and brain ischemia.