In the moderate BD group, highly expressed proteins were primarily involved in defense response (CRP, ORM1, CFH, C1S, RARRES2, CFI, MST1, KRT1, SAA4, HP, TNC, HPR, IFNW1, KNG1, LOC102723996, C9, SAA1, LBP, APOL1, CFB), acute‐phase response (CRP, ORM1, SAA4, SAA1, HP, HPR, LBP), and immune response (CRP, IGHV3‐43D, CFH, C1S, IGHV3‐11, RARRES2, CFI, MST1, KRT1, IFNW1, ICAM1, VTN, AZGP1, LOC102723996, C9, IGHD, ENPP2, LBP, APOL1, CFB). This evidence concerns the gene CFB and Behcet disease.