Using an XGBoost‐based model, key features including TNC, F11, ITIH4.2, FN11, ITIH4, F5, IGHG2, VWF, VTN, APMAP, IGHG1, LRG1, DBI, IGKV1‐27, and SERPINA3 were identified as critical biomarkers for BD severity stratification (Figure 4C). The gene discussed is SERPINA3; the disease is Behcet disease.