In the severe BD group, enriched proteins were predominantly associated with defense response (SERPINA3, ITIH4, COLEC10, FCN3, SERPINA1, TFRC, C1R, CFP, C8B, ORM2, CDH5, C5, PRDX5, C7, TIMP1, MBL2, ANXA1, F12, ADIPOQ, SERPINF2, RNASE4, AGT, ATRN, TF, PROC, MASP1) and protein activation cascade with complement activation (FCN3, C5, COLEC10, C7, C1R, F12, MASP1, C8B, CFP, MBL2) (Figure 3B). This evidence concerns the gene TF and Behcet disease.