Using the XGBoost‐based model, key biomarkers including F11, ITIH4, SERPINA3, APMAP, ORM1, LRG1, ITIH3, FN1, FGL1, FCN3, C1QA, C5, PLTP, TPM3, and IGKV3‐64D were identified as critical variables for BD diagnosis (Figure 2C,D). The gene discussed is ITIH3; the disease is Behcet disease.