For instance, apoA-I mimetic amphipathic peptide 4F integrates into the LDL surface phospholipids and stabilizes apoB-conformation and reduces LDL aggregation [50], while DP3, a retro-enantio peptide derived from LDL-receptor like protein 1, binds directly to apoB-100, maintaining its α-helical structure and reducing aggregation and atherosclerosis [51▪]. The gene discussed is APOB; the disease is atherosclerosis.