Other studies collectively illustrated that the dysregulated gene expression of IGF1, IGF2, SMAD3, CXCR1, ACP5, CEACAM3, S1PR4, and TCF7 matched PCOS disease risk by the nomogram, spurring the dysregulation of ovarian biological processes (regarding transporter activity, catalytic activity, tyrosine phosphorylation of STAT5 protein, and immune response) [44–46]. The gene discussed is SMAD3; the disease is polycystic ovary syndrome.