The identification of virulence genes for PCOS-associated endometrial carcinoma was also analyzed by AI algorithms LASSO, SVM, and the topological matrix, indicating both NAA15 linked to sedentary behavior and ENPP2 in hormonal response within PCOS were the novel biomarker for endometrial carcinoma [130, 131]. This evidence concerns the gene ENPP2 and polycystic ovary syndrome.