MMP9, DAPK1, and P2RY13 tracked by flourishing AI nomogram (LASSO, RF, and SVM) were negatively related with Macrophages M1, translating as PCOS-mediated hub genes in atherosclerosis, with the latent pathogenesis lies in inflammatory response and immunity [132, 133]. This evidence concerns the gene P2RY13 and polycystic ovary syndrome.