TXNIP and Hepatitis: Furthermore, a more in-depth study showed that fructose intake reduced microRNA-200a (miR-200a), targeting Kelch-like ECH-associated protein 1 (Keap1) and inhibiting the Nrf2 antioxidant pathway, thereby triggering the thioredoxin-interacting protein (TXNIP)-activated NLRP3 inflammasome, ultimately inducing liver inflammation [239].