Nrf2 can promote tumor cell proliferation by regulating genes such as PDGFC, NOTCH1, and VEGFC, etc. Moreover, Nrf2 facilitates tumor progression by modulating ATF4-mediated transcriptional control of serine/glycine metabolic pathways, thereby accelerating protein biosynthesis in malignant cells [25]. The gene discussed is NFE2L2; the disease is neoplasm.