ROS-dependent Nrf2 regulation further varies across microenvironments: APE1 mediates ROS-dependent Nrf2 activation in Barrett’s esophageal adenocarcinoma [83], whereas autophagy-related proteins (e.g., SQSTM1/p62) regulate this axis in HCC [84]. The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.