CLOCK and early-onset autosomal dominant Alzheimer disease: Recently, a role of the circadian clock in regulating ChP-specific functions has been ascertained in a study, which showed that the ChP clock regulates rhythmically many ChP-specific processes, including the CSF circadian secretome, endoplasmic reticulum stress response, and expression of genes involved in neurodegenerative diseases (Alzheimer’s disease, Huntington’s disease, and frontotemporal dementia) [11].