In cardiomyocytes, PKA is the well‐established activator in the β‐adrenergic receptor pathway, leading to the phosphorylation of MYBPC3 at specific sites, including Ser273, Ser282, and Ser302.[28] CaMKII is another enzyme that phosphorylates MYBPC3, typically associated with calcium signaling as a player in regulating cardiac function.[48] In this work, we demonstrated that Foxo6os can recruit protein kinase PKC‐α, which in turn mediates phosphorylation of MYBPC3 at the N‐terminal region (Thr289, Ser290, Ser292) during cardiac hypertrophy. The gene discussed is MYBPC3; the disease is cardiac hypertrophy.