On the contrary, overexpression of Foxo6os (Figure S2C,D, Supporting Information) in Ang II‐treated cardiomyocytes could postpone the progression of cardiac hypertrophy, manifesting a significant reduction in the levels of ANP, BNP, and MYH7 compared to the control group (Figure 4G,H), and further confirmed by immunofluorescence (IF) staining (Figure 4I,J,K). Here, NPPA is linked to cardiac hypertrophy.