TNNT2 and hydrops fetalis: To further investigate whether cardiac‐specific knockdown of Foxo6os exacerbates TAC‐induced ventricular remodeling and subsequently accelerates the pathological progression of HF, mice were first injected with AAV9 carrying the cardiac‐specific promoter cTnT and either a Foxo6os interference sequence (AAV9‐shFoxo6os) or negative control sequence (AAV9‐shNC) via tail vein injection, followed by TAC surgery 3 days later (Figure3A).