SETD2 and nonpapillary renal cell carcinoma: In fact, it has been reported that SETD2 catalyses H3K36me3, a classic tumor suppressor marker in ccRCC, participating in, for instance, transcriptional elongation and transcriptional initiation inhibition.[17]SETD2 mutation induces epigenetic remodeling and promotes the malignant progression of ccRCC, but the specific mechanism remains unclear.