The LEDGF PWWP domain and Integrase Binding Domain (IBD) perform the functions of chromatin recognition and protein binding, respectively.[22] In detail, it involves processes such as chromatin and DNA binding, transcriptional regulation, and protein‐protein interactions.[23] LEDGF may bind to other modified sites on histones, and this novel epigenetic axis may mediate metabolic reprogramming of SETD2 mutant ccRCC, leading to poor prognosis. Here, PSIP1 is linked to nonpapillary renal cell carcinoma.