SETD2 and nonpapillary renal cell carcinoma: The LEDGF PWWP domain and Integrase Binding Domain (IBD) perform the functions of chromatin recognition and protein binding, respectively.[22] In detail, it involves processes such as chromatin and DNA binding, transcriptional regulation, and protein‐protein interactions.[23] LEDGF may bind to other modified sites on histones, and this novel epigenetic axis may mediate metabolic reprogramming of SETD2 mutant ccRCC, leading to poor prognosis.