LEDGF IBD domain can combine the mixed lineage leukaemia (MLL1)‐menin complex4 to regulate Hox gene, and then participate in the occurrence of MLL leukemia.[30] In addition, previous studies have focused on exploring the interaction of the LEDGF IBD domain with HIV integrase.[31] These studies all highlight the importance of LEDGF, however, the study of LEDGF in cancer is still scarce. This evidence concerns the gene PSIP1 and cancer.