LEDGF regulates gene expression and is involved in vital biological processes such as DNA damage repair, playing an indispensable role in maintaining genome stability.[18] Previous studies focused on the role of LEDGF in Human Immunodeficiency Virus (HIV) infection and Mixed Lineage Leukemia gene (MLL) leukemia,[19, 20] overlooking its vital functions in solid tumors. The gene discussed is PSIP1; the disease is leukemia.