PSIP1 and nonpapillary renal cell carcinoma: In fact, LEDGF is dysregulated in a variety of solid tumors and is overexpressed in ccRCC.[16] The LEDGF Proline‐Tryptophan‐Tryptophan‐Proline (PWWP) domain is reported as a member of the “Royal” family, and is the classic reader of H3K36me3.[21] As a vital chromatin localization protein, LEDGF acts as a molecular bridge.