It was recently reported that increased ORC6 expression is closely associated with tumor progression and an unfavorable prognosis in NSCLC patients.[63] We found that depleting ORC6 significantly inhibited NSCLC cell proliferation, EdU incorporation, and S phase progression and reversed the effects of ETV4 on cell proliferation and EdU incorporation, which indicated the essential role of ORC6 in ETV4‐regulated tumor cell proliferation and replication. The gene discussed is ETV4; the disease is non-small cell lung carcinoma.