In addition, the largest subunit ORC1 is reported to be degraded after the initiation of replication; its rebinding to chromatin is an obligatory step for the establishment of the pre‐RC in G1.[64] We found that ETV4 controls the total expression and chromatin‐bound ORC1, ensuring a sufficient amount for origin licensing in NSCLC cells. Here, ORC1 is linked to non-small cell lung carcinoma.