The nuclear staining of MCM2, ‐4, ‐5, ‐10, and ORC1 was positive in 56.79%, 55.56%, 51.85%, 44.44%, and 50.62% of tumor tissues, respectively, and were all positively associated with tumor size, lymph node metastasis, and TNM stage (all p < 0.05, Figure S19E, Table S1,S2, Supporting Information). Here, ORC1 is linked to neoplasm.