Subsequently, G3BP1, YBX1, and p53 interact with each other, the amount of synergistic nuclear translocation of YBX1 and p53 is reduced, and the level of p53 nuclear translocation that inhibiting SLC7A11 transcription is decreased, thereby inhibits cardiomyocyte ferroptosis and reducing myocardial tissue damage during myocardial IRI in diabetes. Here, SLC7A11 is linked to diabetes mellitus.