ALKBH5 and ischemic disease: Studies have shown that ALKBH5 plays important roles in cardiomyocyte proliferation and cardiac regeneration,[6] ischemic diseases,[7] blood diseases,[8] and tumors.[9] Studies have also shown that m6A modification is closely related to the hypoxia‒reoxygenation process in cardiomyocytes,[10] but the specific mechanism by which ALKBH5 is involved and how it affects diabetic myocardial ischemia‒reperfusion injury are still unknown.