Our previous study revealed that during acute liver failure, the NTF2 and RRM domains of the G3BP1 protein can bind to the NLS sequence of p53, preventing p53 from being incorporated into the nucleus to bind to the promoter region of SLC7A11, a ferroptosis regulator, and promote the transcription of SLC7A11, thereby inhibiting ferroptosis in hepatocytes.[16] Thus, G3BP1 is regulated by both ALKBH5 and ferroptosis. Here, G3BP1 is linked to acute liver failure.