To gain further insights into the transcription factors downstream of ChREBPα that antagonize TGF‐β action, we therefore performed in‐depth analysis of our RNA‐Seq data (GSE223649) and microarray data (GSE164321)[11, 29] and identified several fibrosis‐associated transcription factors, including E2f1,[31]Foxm1,[32]Bcl6,[33]Atf3,[34]Esrrg,[35]Pax8,[36] and Egr3,[31a] that were upregulated in the liver of NASH diet‐fed Chrebpα‐LKO mice (Figure6A, left panel). Here, E2F1 is linked to metabolic dysfunction-associated steatohepatitis.