Our study establishes hepatocyte ChREBPα as a potent anti‐fibrogenesis factor in chronic liver injury by antagonizing TGFb‐E2F1‐THBS1/CTGF signaling pathway, directly linking persistently overactive hepatocyte TGFβ signaling to liver fibrosis. The gene discussed is TGFB1; the disease is Hepatic fibrosis.