H&E staining of the liver indicated severe and diffuse necrosis in ChREBPα‐LKO mice, which also developed more advanced liver fibrosis, indicated by the elevated a‐SMA protein and Sirius staining and COL1A1 IHC (Figure 2D,G; Figure S1C, Supporting Information). Here, COL1A1 is linked to Hepatic fibrosis.