E2F1 and Hepatic fibrosis: All these results showed that acute depletion of hepatic E2f1 alleviates liver fibrosis in CCl4‐injected Chrebpα‐LKO mice (Figure 7D,E), supporting that hepatocyte ChREBPα‐specific anti‐fibrosis action is mediated via inhibiting E2F1 in vivo.