A recent study suggests that ChREBP transcriptionally inhibits Cyclin D1 in gastric cancer cells and the expression of ChREBP was reduced in gastric cancer, liver cancer, and colorectal cancer tissues.[46] Thus, it is conceivable that the downregulation of ChREBP may also change the tumor microenvironment and impact the activity of tumor‐associated fibroblasts. The gene discussed is MLXIPL; the disease is colorectal cancer.