ATP2A2 and Zika virus infectious disease: In contrast, when U251 cells were infected by ZIKV/SZ01, the concentration of intracellular Ca2+ in the shSERCA2 group was significantly lower than that of the shRNA group (Fig. 2F and G), confirming that SERCA2 was involved in the regulation of the imbalance of Ca2+ homeostasis caused by ZIKV infection.