SREBF1 and neoplasm: Additionally, the tumorigenicity of shSmyd3 cells increased upon Srebp1 overexpression and was comparable to that of nontarget controls in an orthotopic syngeneic mouse tumor model in vivo (Figure 7E,F), and the pattern of Th2 cell infiltration was similar to the tumorigenicity (Figure 7G; Figure S8, Supporting Information).