SMYD3 expression was upregulated at both the mRNA and protein levels (Figure S1A–D, Supporting Information), which was in line with the findings of previous studies of other types of tumors.[12] We established stable Smyd3 knockdown RENCA cells, and Smyd3 knockdown impaired tumor growth in an orthotopic syngeneic mouse model in vivo (Figure S2A–D, Supporting Information). Here, SMYD3 is linked to neoplasm.