We first investigated the effect of SMYD3 on infiltrating immune cell type through single sample Gene Set Enrichment Analysis (ssGSEA) on the basis of RNA‐seq information from ccRCC datasets (TCGA, E‐MATAB‐1980, ICGC‐RECA‐EU, GSE167093, GSE73731 and GSE40435), which include more than 100 cases of ccRCC, with the exception of ICGC‐RENCA‐EU (n = 91). This evidence concerns the gene SMYD3 and nonpapillary renal cell carcinoma.