Next, we identified 9 immune‐related DEGs that fulfilled two criteria: (1) they were significantly deregulated by SMYSD3 in TK10 cells, and (2) they were included in an immune‐related gene set (Table S2, Supporting Information).[23] Among these 9 immune‐related genes, 4 (CD276, CD47, SIRPα, and VTCN1) are inhibitory checkpoint targets that mediate immune evasion and might be regulated by SMYD3 in ccRCC (Figure3A). Here, SIRPA is linked to nonpapillary renal cell carcinoma.