To gain more insight into the immune landscape changes induced by SMYD3 in ccRCC, we established a stable Smyd3‐knockdown RENCA cell line by short hairpin RNA (shRNA) lentivirus and generated scRNA‐seq profiles of FACS‐sorted CD45+ immune cells isolated from tumors in orthotopic syngeneic renal cell carcinoma BALB/c mice using 10× Genomics sequencing (Figure 1C). Here, PTPRC is linked to hereditary clear cell renal cell carcinoma.