The interactions between tumor cells and the microenvironment are key in carcinogenesis and tumor progression, and immune cells play pivotal roles in the tumor microenvironment (TME).[15] RCC stands out as one of the most common immune‐infiltrated tumors in pan‐cancer comparisons.[16] We subsequently assessed the role of cancer cell‐intrinsic SMYD3 in the tumor immune microenvironment (TIME) of ccRCC. This evidence concerns the gene SMYD3 and renal cell adenocarcinoma.