SMYD3 and neoplasm: Recently, we noticed that the immunomodulatory role of SMYD3 has been reported in the HPV‐negative head and neck squamous cell carcinoma mouse models.[17] In their study, researchers found that while Smyd3 anti‐sense oligonucleotides (ASOs) did not affect the cell abundance of tumor infiltrating immune cells, they did influence the functional status of these cells by impacting their transcriptional profiles.