In this study, we performed bioinformatic analysis and single‐cell RNA sequencing (scRNA‐seq), and we determined that SMYD3 promotes the infiltration of T helper 2 (Th2) cells and knockdown of SMYD3 strengthens the anti‐PD‐1 response in ccRCC cells. This evidence concerns the gene SMYD3 and nonpapillary renal cell carcinoma.