CD47 is an innate immune checkpoint ligand that is expressed in many types of cancers, and plays a crucial role in macrophage/dendritic cell‐mediated phagocytosis upon binding to the receptor SIRPα, which is expressed mainly on myeloid cells.[24, 37] Moreover, CD47 can influence the infiltration of immune effector cells (e.g., T cells) in the TME because of its role as a bridge between innate and adaptive immunity.[24b] Our results suggest that CD47, an inhibitory immune molecule downstream of SMYD3, mediates the immunosuppressive function of SMYD3 in ccRCC. Here, SMYD3 is linked to cancer.