However, knockdown Smyd3 expression of tumor cells could impact the transcriptional changes in tumor‐infiltrating neutrophils and macrophages, especially the expression of Cebpb (Figure S4F, Supporting Information), which encodes a crucial transcription factor for emergency granulopoiesis and monocyte/macrophage gene regulation,[18] and is well known for its role in immunosuppression.[19]. The gene discussed is SMYD3; the disease is neoplasm.