SIRPα is a transmembrane protein that binds to the extracellular Ig‐domain of CD47, and is expressed on myeloid cells, especially macrophages and dendritic cells, where it regulates phagocytosis and mediates the “don't eat me” signal upon binding to its ligand CD47 on tumor cells; the activity of the CD47/ SIRPα axis impairs innate and adaptative immunity.[24] We subsequently performed stable knockdown of SMYD3 in TK10 and 786‐O cells using shRNA lentivirus and RT‐qPCR to verify the alterations in the expression levels of CD276 and CD47 (Figure 3C). The gene discussed is SIRPA; the disease is neoplasm.