SMYD3 and nonpapillary renal cell carcinoma: In this study, we found that upregulated SMYD3 expression was closely related to the tumor immune microenvironment, orchestrating an inhibitory immune microenvironment in ccRCC by affecting the transcriptome profiles of tumor‐infiltrating immune cells and the landscape of immune cell infiltration (e.g., Th2 cells) in the TME of ccRCC.