EGFR and cancer: Mutation or elevated expression of EGFR promotes cancer development and is leveraged as a primary target of TKIs.[9, 45] It is therefore of great interest to elucidate how EGFR is regulated, which is not fully understood despite many investigations.[45, 46, 47] We reveal that RAC1B, via interaction with GDS1, strongly promotes EGFR protein expression by preventing its lysosomal sorting and degradation, highlighting a new regulatory mechanism of EGFR.