Finally, we did not have access to additional prognostic information (e.g., gene expression profiles, chromosome 3 status, mutations in BAP1, SF3B1, EIF1AX genes) or clinical features that could further characterize lesion malignancy, as all lesions diagnosed as melanomas were treated promptly with plaque brachytherapy.18 The gene discussed is EIF1AX; the disease is melanoma.