SORL1 and early-onset autosomal dominant Alzheimer disease: Two knockout genes interacted with the GWAS AMD genes: sortilin-related receptor 1 (SORL1), a gene coding for a receptor involved in intracellular sorting of protein which is primarily associated with Alzheimer disease,20 and tyrosine aminotransferase (TAT), which is involved in the tyrosine breakdown pathway (Fig. 3C).