When KEGG Mapper was used to assess the human ortholog found set in the context of known IRD genes from RetNet, several overlapping pathways were identified: apelin signaling, cholinergic synapse, glutamatergic synapse, GABAergic synapse, pathways in cancer, Ras signaling pathway, chemokine signaling pathway, Kaposi sarcoma-associated herpesvirus infection, retrograde endocannabinoid signaling, PI3K/Akt pathway, and cytomegalovirus infection. This evidence concerns the gene AKT1 and cancer.