PPM1G and cancer: Many studies have focussed on mTORC1 regulation of translation on the control of cell growth, particularly in cancer settings (Liu and Sabatini, 2020), and previous work has shown that endogenous PP2Cγ/ PPM1G contributes to 4E-BP1 dephosphorylation in 293 and HCT116 cells (Liu et al., 2013).