AKT1 and central nervous system cancer: Additionally, in glioblastoma, knockdown models showed that C1GALT1 enhances the progression of glioma by regulating the O‐glycosylation and phosphorylation of EGFR and the subsequent downstream AKT/ERK signaling pathway [32], which was similar to our survival results showing that high C1GalT1 expression causes decreased OS.