CDH1 and type 2 diabetes mellitus: Our previous studies reported that a long duration of T2D (≥ 3 years) was correlated with a high frequency of CDH1 promoter methylation and that a high level of HbA1c (≥ 6.5%) was correlated with high expression of miR-100-5p, resulting in low expression of E-cadherin, epithelial-mesenchymal transition, poor prognosis, and malignant behavior in patients with PDAC (21–23).