ALB and diabetic kidney disease: It also has unique functions in DKD, as it is exposed to and reabsorbs high levels of glucose, albumin, and fatty acids; proximal tubular reabsorption of glucose and sodium in the diabetic kidney leads to suppressed tubuloglomerular feedback and thus renal vasodilation, contributing to the glomerular hyperfiltration in early DKD, which is just one of many roles of the proximal tubule in this disease state (48).