According to RNA-Seq or snRNA-Seq analyses of tissues from disease models or patients, oligodendrocytes in MS exhibited immune-related gene alterations (51), whereas oligodendrocytes in AD exhibited stress-related transcriptomic dysregulation associated with Erk signaling, tau pathology, and cognitive decline (54), suggesting pathological differences among neurodegenerative diseases. This evidence concerns the gene MAPT and Mental deterioration.